Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)
Jennifer N. Rauch, John Jing-Wei Chen, Alexander W. Sorum, Gregory M. Miller, Tal Sharf, Stephanie K. See, Linda C. Hsieh‐Wilson, Martin Kampmann, Kenneth S. Kosik
The paper identifies 6-O-sulfation on heparan sulfate proteoglycans as critical for tau internalization and shows it regulates uptake in multiple cell models.
Scientific Reports · Apr 17, 2018Peer-reviewedNeuroscience