Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury
Mai Yamamoto, Dipankar Ash, Sudhahar Varadarajan, Syed Adeel H. Zaidi, Modesto Rojas, Zhimin Xu, Stephanie Sinclair Kelley, Ruth B. Caldwell, Tohru Fukai, Masuko Ushio‐Fukai
This study shows that CTR1 contributes to retinal ischemia-reperfusion injury by promoting oxidative stress and inflammation, and that copper chelators like TTM can mitigate these effects.
bioRxiv · May 17, 2025 · PreprintCell Biology