Author

Modesto Rojas

Augusta UniversityORCID 0000-0002-9441-3302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Mai YamamotoiD· 3 shared Ruth B. CaldwelliD· 3 shared Syed Adeel H. ZaidiiD· 3 shared Zhimin XuiD· 3 shared Porsche V. Sandow· 2 shared Robert W. CaldwelliD· 2 shared Tahira Lemtalsi· 2 shared Dipankar AshiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

Mai YamamotoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PEG-Arginase 1: A Novel Therapy for Optic Nerve Injury

Mai Yamamoto, Syed Adeel H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Porsche V. Sandow, Robert W. Caldwell, Ruth B. Caldwell, Modesto Rojas

This paper demonstrates that PEG-A1 treatment reduces retinal injury and preserves vision after optic nerve trauma by modulating the ornithine/polyamine pathway.

bioRxiv · Aug 27, 2026 · PreprintCell Biology

Novel Role of AcylCoA:cholesterol acyltransferase 1 (ACAT1/SOAT1) in Diabetic Retinopathy

Syed Adeel H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Mai Yamamoto, Porsche V. Sandow, Steven E. Brooks, Robert W. Caldwell, Ruth B. Caldwell, Modesto Rojas

Inhibiting cholesterol esterification limits retinal neurovascular injury in diabetes.

bioRxiv · Oct 9, 2025 · PreprintCell Biology

Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury

Mai Yamamoto, Dipankar Ash, Sudhahar Varadarajan, Syed Adeel H. Zaidi, Modesto Rojas, Zhimin Xu, Stephanie Sinclair Kelley, Ruth B. Caldwell, Tohru Fukai, Masuko Ushio‐Fukai

This study shows that CTR1 contributes to retinal ischemia-reperfusion injury by promoting oxidative stress and inflammation, and that copper chelators like TTM can mitigate these effects.

bioRxiv · May 17, 2025 · PreprintCell Biology