Caroline Gubser Keller

This study investigates the specificity of splicing modulators by analyzing their interactions with RNA structures and demonstrates reprogramming of their specificity through genetic manipulation of the spliceosome.

DRUG-seq provides high-throughput, unbiased transcriptomic data for drug discovery, demonstrating reproducibility and mechanism-of-action resolution for diverse compounds.

This study shows that reduced TREM2 proteolytic cleavage in mice increases microglial heterogeneity and accelerates Abeta pathology in Alzheimer's disease.

The paper benchmarks scRNA-seq methods and introduces CellSIUS, a tool that improves detection of rare cell populations and identifies their functional signatures in human stem cell differentiation.