mRNA N1-2'O-methylation by CMTR1 affects NVL2 mRNA splicing
Steven Wolter, Thomas Hennig, Christina Wallerath, Thais Marina Schlee-Guimaraes, Alexander Kirchhoff, Christian Urban, Antonio Piras, Alexey Stukalov, Stefan Juranek, Michael Engelke, Volker Boehm, Niels H. Gehring, Gunther Hartmann, Andreas Pichlmair, Caroline C. Friedel, , Martin Schlee
This study shows that CMTR1-mediated N1-2'O-methylation prevents antiviral recognition and regulates NVL2 mRNA splicing, affecting cell size, division, and ribosome biogenesis.
bioRxiv · Sep 28, 2023 · PreprintMolecular Biology