Andreas Pichlmair

The paper identifies apolipoprotein C1 as a host factor that facilitates HBV and HDV infection by associating with viral particles and enhancing infectivity through SR-B1.

This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.

This study identifies ZDHHC17-mediated palmitoylation of HEV ORF3 protein as critical for directional secretion in polarized epithelial cells.

HCR-Proxy maps RNA-proximal proteomes at subcompartmental resolution, revealing sequence-encoded protein partitioning in nucleolar condensates.

Modanovo is a de novo peptide sequencing model that handles post-translational modifications, outperforming existing methods and complementing database searches in phosphoproteomics.

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

This paper introduces a method to isolate N-termini for proteome analysis, demonstrating its application in identifying cleaved proteins during apoptosis.

This study reveals the structural basis of OAS2 regulation and its antiviral function, showing how it discriminates RNA length and restricts viruses like coronaviruses.

This study shows that CMTR1-mediated N1-2'O-methylation prevents antiviral recognition and regulates NVL2 mRNA splicing, affecting cell size, division, and ribosome biogenesis.

This study shows that ZAP restricts HCMV infection by destabilizing viral transcripts with low CG content, revealing its role in antiviral defense against DNA viruses.

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.