Antonio Piras

A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness

This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.

ZDHHC17-Mediated Palmitoylation of Hepatitis E Virus ORF3 Protein Regulates Vectorial Trafficking in Polarized Epithelial Cells

This study identifies ZDHHC17-mediated palmitoylation of HEV ORF3 protein as critical for directional secretion in polarized epithelial cells.

mRNA N1-2'O-methylation by CMTR1 affects NVL2 mRNA splicing

This study shows that CMTR1-mediated N1-2'O-methylation prevents antiviral recognition and regulates NVL2 mRNA splicing, affecting cell size, division, and ribosome biogenesis.

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts cytomegalovirus

This study shows that ZAP restricts HCMV infection by destabilizing viral transcripts with low CG content, revealing its role in antiviral defense against DNA viruses.

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.