This study shows that CMTR1-mediated N1-2'O-methylation prevents antiviral recognition and regulates NVL2 mRNA splicing, affecting cell size, division, and ribosome biogenesis.

bioRxiv · Sep 28, 2023 · PreprintMolecular Biology

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts cytomegalovirus

Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, Thomas Hennig, Sabina Ganskih, Yuanjie Wei, Albert Heim, Markus Landthaler, Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann

This study shows that ZAP restricts HCMV infection by destabilizing viral transcripts with low CG content, revealing its role in antiviral defense against DNA viruses.

mBio · May 3, 2021Peer-reviewedMolecular Biology

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Alexey Stukalov, Virginie Girault, Vincent Grass, Özge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, , Andreas Pichlmair

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.

Nature · Apr 12, 2021Peer-reviewedSystems Biology✦ In-depth digest