Non-homologous end-joining is implicated in rapid and efficient caspofungin adaptation in Nakaseomyces glabratus
Laetitia Maroc, Nicholas C Gervais, Meea Fogal, Eileen Bates, Garrett Westmacott, Peter McQueen, Stuart McCorrister, Christopher Grant, Sydney Johnson, Rebecca S Shapiro
This study shows that non-homologous end joining (NHEJ) facilitates rapid adaptation to caspofungin in Nakaseomyces glabratus by enabling FKS2 mutations, while NHEJ-deficient strains adapt less efficiently through alternative pathways.
bioRxiv · Nov 4, 2026 · PreprintMicrobiology