Enhancers predominantly regulate gene expression in vivo via transcription initiation.
Martin Larke, Takayuki Nojima, Jelena M. Telenius, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Sue Butler, Robert A. Beagrie, Damien J. Downes, Ron Schweßinger, A. Marieke Oudelaar, Julia Truch, Bryony Crompton, M. A. Bender, Nicholas J. Proudfoot, Douglas R. Higgs, Jim R. Hughes
This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.
bioRxiv · Nov 16, 2019 · PreprintGenomics