Jacqueline A. Sloane-Stanley

On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation

The paper uses live-cell imaging to study transcriptional bursting dynamics during mouse erythropoiesis, finding changes in burst patterns associated with differentiation stages.

Multipartite super-enhancers function in an orientation-dependent manner

The paper shows that super-enhancers function directionally and orientation-dependently, unlike regular enhancers, by analyzing the β-globin super-enhancer.

A functional overlap between actively transcribed genes and chromatin boundary elements

The paper shows that actively transcribed genes can function as chromatin boundary elements, similar to CTCF-bound sites, by stalling chromatin loop extrusion.

Identification of MAZ as a novel transcription factor regulating erythropoiesis

This study identifies MAZ as a novel transcription factor regulating erythropoiesis by binding to the -globin gene promoter and interacting with GATA1-bound enhancers, with knockdown impairing differentiation and genetic variants linked to erythroid traits.

Enhancers predominantly regulate gene expression in vivo via transcription initiation.

This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.