Author

Jacqueline A. Sharpe

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Damien J. DownesiD· 3 shared Douglas R. HiggsiD· 3 shared Jacqueline A. Sloane-Stanley· 3 shared Jelena M. TeleniusiD· 3 shared Jim R. HughesiD· 3 shared A. Marieke OudelaariD· 2 shared Caroline L. HarroldiD· 2 shared Martin LarkeiD· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Damien J. DownesORCID

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3 papers

Recent·Most cited

Multipartite super-enhancers function in an orientation-dependent manner

Mira T. Kassouf, Helena S. Francis, Matthew E. Gosden, Maria Suciu, Damien J. Downes, Caroline L. Harrold, Martin Larke, A. Marieke Oudelaar, Lucy Cornell, Joseph Blayney, Jelena M. Telenius, Barbara Xella, Yuki Shen, Nikolaos Sousos, Jacqueline A. Sharpe, , Douglas R. Higgs

The paper shows that super-enhancers function directionally and orientation-dependently, unlike regular enhancers, by analyzing the β-globin super-enhancer.

bioRxiv · Jul 14, 2022 · PreprintMolecular Biology

A functional overlap between actively transcribed genes and chromatin boundary elements

Caroline L. Harrold, Matthew E. Gosden, Lars L P Hanssen, Rosa J. Stolper, Damien J. Downes, Jelena M. Telenius, Daniel Biggs, Chris Preece, Samy Alghadban, Jacqueline A. Sharpe, Benjamin Davies, Jacqueline A. Sloane-Stanley, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs

The paper shows that actively transcribed genes can function as chromatin boundary elements, similar to CTCF-bound sites, by stalling chromatin loop extrusion.

bioRxiv · Jul 1, 2020 · PreprintGenomics

Enhancers predominantly regulate gene expression in vivo via transcription initiation.

Martin Larke, Takayuki Nojima, Jelena M. Telenius, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Sue Butler, Robert A. Beagrie, Damien J. Downes, Ron Schweßinger, A. Marieke Oudelaar, Julia Truch, Bryony Crompton, M. A. Bender, Nicholas J. Proudfoot, Douglas R. Higgs, Jim R. Hughes

This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.

bioRxiv · Nov 16, 2019 · PreprintGenomics