Author

M. A. Bender

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Marieke OudelaariD· 1 shared Bryony Crompton· 1 shared Damien J. DownesiD· 1 shared Douglas R. HiggsiD· 1 shared Jacqueline A. Sharpe· 1 shared Jacqueline A. Sloane-Stanley· 1 shared Jelena M. TeleniusiD· 1 shared Jessica M. Halow· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenomics

A. Marieke OudelaarORCID

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2 papers

Recent·Most cited

Tissue context determines the penetrance of regulatory DNA variation

Jessica M. Halow, Rachel Byron, Megan S. Hogan, Raquel Ordóñez, Mark T. Groudine, M. A. Bender, John A. Stamatoyannopoulos, Matthew T. Maurano

The paper quantifies how tissue context influences the effect of regulatory DNA variants on transcription factor activity using allelic accessibility maps in mice.

Nature Communications · May 14, 2021Peer-reviewedGenomics

Enhancers predominantly regulate gene expression in vivo via transcription initiation.

Martin Larke, Takayuki Nojima, Jelena M. Telenius, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Sue Butler, Robert A. Beagrie, Damien J. Downes, Ron Schweßinger, A. Marieke Oudelaar, Julia Truch, Bryony Crompton, M. A. Bender, Nicholas J. Proudfoot, Douglas R. Higgs, Jim R. Hughes

This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.

bioRxiv · Nov 16, 2019 · PreprintGenomics