Martin Larke

Multipartite super-enhancers function in an orientation-dependent manner

The paper shows that super-enhancers function directionally and orientation-dependently, unlike regular enhancers, by analyzing the β-globin super-enhancer.

An integrated platform to systematically identify causal variants and genes for polygenic human traits.

The paper develops a platform combining ATAC-seq, DNaseI footprints, NG Capture-C, and machine learning to identify causal variants and genes for polygenic human traits.

Enhancers predominantly regulate gene expression in vivo via transcription initiation.

This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.