Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment
Daniel J. W. Chong, Laura-Oana Albulescu, Adam Westhorpe, Rachel H. Clare, Amy E. Marriott, Christopher M. Woodley, Gunasekar Ramachandran, Nada Mosallam, Edouard Crittenden, Emma L. Stars, Charlotte A. Dawson, Jeroen Kool, Mark C. Wilkinson, Suet C. Leung, Neil G. Berry, , Paul M. O’Neill
This paper develops DC-174, an oral small molecule that inhibits snake venom metalloproteinases and shows efficacy in a mouse model of envenoming.
bioRxiv · May 23, 2025 · PreprintPharmacology & Toxicology