Adam Westhorpe

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

This study evaluates repurposed drugs against venoms from the Bothrops snake genus, finding that metalloproteinase inhibitors effectively neutralize multiple venom effects.

Establishment of snake venom gland organoids from a novel family, Colubridae

This study establishes venom gland organoids from Colubridae snakes and shows in vitro toxin production.

Snake venom metalloproteinases are predominantly responsible for the cytotoxic effects of certain African viper venoms

This study identifies snake venom metalloproteinases (SVMPs) as the main cytotoxic agents in two African viper venoms and shows EDTA can inhibit their effects.

Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment

This paper develops DC-174, an oral small molecule that inhibits snake venom metalloproteinases and shows efficacy in a mouse model of envenoming.

A drug combinational therapy consisting of toxin phospholipase A2 and metalloproteinase inhibitors provides preclinical protection against North American Crotalid snakebite envenoming

This study evaluates drug combinations to treat snakebite envenoming, finding that combining SVMP and PLA2 inhibitors provides broad protection against lethal effects.

Intraspecific venom variation in the medically important puff adder (Bitis arietans): comparative venom gland transcriptomics, in vitro venom activity and immunological recognition by antivenom

This study compares venom variation in Bitis arietans across three regions using transcriptomics, chromatography, and functional assays, finding substantial toxin variation but no major impact on antivenom efficacy.