Senescent CD8+ T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to Immunotherapy
Paolo S. Turano, Elizabeth Akbulut, Nica Mariz Aquino, Luis Garza-Martínez, Sukhwinder Singh, George S. Yap, Patricia Fitzgerald-Bocarsly, Ricardo Iván Martínez-Zamudio, Utz Herbig
This study identifies senescent CD8+ T effector memory cells as functionally impaired and enriched in aging and disease, and shows they hinder immunotherapy responses.
bioRxiv · Dec 19, 2025 · PreprintCell Biology