Gut mucin fucosylation dictates the entry of botulinum toxin complexes
Sho Amatsu, Takuhiro Matsumura, Chiyono Morimoto, Sunanda Keisham, Yoshiyuki Goto, Tomoko Kohda, Jun Hirabayashi, Kengo Kitadokoro, Takane Katayama, Hiroshi Kiyono, Hiroaki Tateno, Masahiko Zuka, Yukako Fujinaga
The paper shows that fucosylation of intestinal mucin determines the entry routes and oral toxicity of botulinum toxin complexes.
Nature Communications · Nov 25, 2025Peer-reviewedMicrobiology