LRP1 is an entry receptor for the botulinum toxin complex in the gut
Sho Amatsu, Takuhiro Matsumura, Chiyono Morimoto, Hideo Yagita∥, Kiyo‐aki Ishii, Takashi Kanaya, Koji Hase, Nobuhide Kobayashi, Masahiko Zuka, Hiroshi Ohno, Toshinari Takamura, Yukako Fujinaga
This study identifies LRP1 as the receptor for L-PTC/BOkra to enter the gut, showing HA binds to LRP1 via N-glycans and facilitates transcytosis.
bioRxiv · Jun 26, 2026 · PreprintMicrobiology