Conserved reduction of m6A marks during aging and neurodegeneration is linked to altered translation of synaptic transcripts
Ricardo Castro-Hernández, Tea Berulava, Mariia Metelova, Robert Epple, Tonatiuh Peña Centeno, M. Sadman Sakib, Susanne Burkhart, Momchil Ninov, Katherine E. Bohnsack, Markus T. Bohnsack, Ivana Delalle, André Fischer
The paper examines m6A RNA methylation changes in mouse and human brains during aging and Alzheimer's disease, finding reduced m6A levels in synaptic transcripts and impaired synaptic protein synthesis.
bioRxiv · Jun 8, 2022 · PreprintNeuroscience