Tonatiuh Peña Centeno

The lncRNA Gm16685/MITA1 modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signaling

The paper identifies Gm16685/MITA1 as a lncRNA that regulates astrocyte reactivity through PCBP2-mediated modulation of IKKβ signaling in inflammatory conditions.

lncRNA 3222401L13Rik/ENSG00000272070 modulates microglial inflammatory programs in association with PU.1

This paper identifies a lncRNA, 3222401L13Rik/ENSG00000272070, that modulates microglial inflammatory responses through interaction with PU.1 and is reduced in Alzheimer's disease brains.

A role for astrocytic miR-129-5p in Frontotemporal Dementia

This study identifies miR-129-5p as a deregulated microRNA in FTD patients, showing its role in astrocyte dysfunction and neurodegeneration.

Conserved reduction of m6A marks during aging and neurodegeneration is linked to altered translation of synaptic transcripts

The paper examines m6A RNA methylation changes in mouse and human brains during aging and Alzheimer's disease, finding reduced m6A levels in synaptic transcripts and impaired synaptic protein synthesis.

Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes

This study shows that SETD1B is crucial for learning and regulates neuronal plasticity genes in the postnatal brain through H3K4me3 modification.

SETD1B controls cognitive function via cell type specific regulation of neuronal identity genes

The paper shows that Setd1b regulates neuronal identity genes in the adult brain, affecting cognitive function and memory, with other KMTs compensating for its absence.