M. Sadman Sakib

This paper identifies a lncRNA, 3222401L13Rik/ENSG00000272070, that modulates microglial inflammatory responses through interaction with PU.1 and is reduced in Alzheimer's disease brains.

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

This study identifies 3222401L13Rik as an aging-upregulated lncRNA in astrocytes that enhances neuronal support through interaction with Npas3, suggesting it may delay age-related cognitive decline.

This study analyzes single-cell transcriptomes of the mouse hippocampus after voluntary exercise, identifying molecular changes related to neurogenesis and signaling pathways.

The paper examines m6A RNA methylation changes in mouse and human brains during aging and Alzheimer's disease, finding reduced m6A levels in synaptic transcripts and impaired synaptic protein synthesis.

The paper shows H3K9ac increases basal progenitor proliferation and neocortex size by upregulating TRNP1 in evolution.

This study shows that SETD1B is crucial for learning and regulates neuronal plasticity genes in the postnatal brain through H3K4me3 modification.

This study shows heart failure causes hippocampal gene-expression changes leading to memory impairment in mice, and suggests a drug to improve cognition in heart failure patients.

The paper shows that Setd1b regulates neuronal identity genes in the adult brain, affecting cognitive function and memory, with other KMTs compensating for its absence.

This study identifies age-related downregulation of CHST3 gene expression in the aging mouse brain, linked to epigenetic changes and cognitive decline.