Murine CMV Infection Unmasks Macrophage-Driven Inflammatory Cardiomyopathy in Pkp2, but not in Ttn Mutant Mice
Alexandra Cirnu, Tatjana Williams, Mike Noerpel, Julian Kammerer, Svenja Kannt, Mairin Heil, Laura Kimmel, Paula-Anahi Arias-Loza, Manivel Lhoda, Thomas Hennig, DiyaaElDin Ashour, Sarah‐Lena Puhl, Giuseppe Rizzo, Clément Cochain, Tobias Krammer, , Brenda Gerull
This study shows that murine cytomegalovirus infection exacerbates inflammation in Pkp2 mutant mice but not in Ttn mutant mice, highlighting the interaction between genetic predisposition and environmental factors in cardiomyopathy.
bioRxiv · Jan 28, 2026 · PreprintImmunology