Clément Cochain

Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis

The paper shows that promoting soluble FLT1 over full-length FLT1 enhances postischemic angiogenesis by modulating gene isoform expression through APA.

TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium

This study shows TREM2 drives pro-scarring macrophage accumulation in infarcted myocardium, leading to fibrosis and reduced cardiac repair.

Murine CMV Infection Unmasks Macrophage-Driven Inflammatory Cardiomyopathy in Pkp2, but not in Ttn Mutant Mice

This study shows that murine cytomegalovirus infection exacerbates inflammation in Pkp2 mutant mice but not in Ttn mutant mice, highlighting the interaction between genetic predisposition and environmental factors in cardiomyopathy.

Mucosal-Associated Invariant T Cells Promote Atherosclerosis Through Monocyte-Driven Inflammation

This study identifies MAIT cells as contributors to atherosclerosis through monocyte-driven inflammation, showing their enrichment in plaques and protective effects when depleted.

Neutrophil terminal programming in the ischemic heart drives fibrosis after myocardial infarction

This study shows that neutrophils in the ischemic heart undergo terminal programming to drive fibrosis after myocardial infarction.

CD4+ T cells fuel the Duchenne cardiomyopathy

This study shows CD4+ T cells drive cardiomyopathy in Duchenne muscular dystrophy by promoting fibrosis and dysfunction, using Mdx mice and single-cell RNA sequencing.

Targeting platelet GPVI or GPIIb/IIIa only minimally affect acute inflammation and cardiac repair in experimental permanent myocardial infarction

MACanalyzeR: scRNA-seq Analysis Tool Reveals PPARγHI Lipid-Associated Macrophages Facilitate Thermogenic Expansion in BAT

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.