Maintenance of neuronal TDP-43 expression requires axonal lysosome transport
Veronica H. Ryan, Sydney Lawton, Joel F. Reyes, James Hawrot, Ashley M. Frankenfield, Sahba Seddighi, Daniel M. Ramos, Jacob Epstein, Faraz Faghri, Nicholas L. Johnson, Jizhong Zou, Martin Kampmann, John Michael Replogle, Yue A. Qi, Hebao Yuan, , Michael Emmerson Ward
The paper identifies BORC as a modifier of TDP-43 protein levels in neurons, showing lysosome transport is required for TDP-43 turnover.
eLife · Sep 1, 2025Peer-reviewedNeuroscience