Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas.
Maxwell Thomas Laws, Dhruval Bhatt, Debjani Mandal, Nikhil Ramavenkat, David T. Asuzu, Stefan Stoica, Ihika Rampalli, Dustin Mullaney, Liyam Laraba, Hannah Odom, Niveditha Ravindra, Sheelu Varghese, Tracy Tzu-Ling Tang, Xiyuan Zhang, John Frederick Shern, , Prashant Chittiboina
The paper identifies variable merlin inactivation in schwannomas and shows TEAD1 inhibition can reverse hippo signaling and suppress tumor growth.
bioRxiv · Nov 15, 2025 · PreprintCancer Biology