Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages
Pamelia N. Lim, Maritza M. Cervantes, Linh K. Pham, Sydney R Doherty, Ankita Tufts, Divya Dubey, Dat Mai, Alan A. Aderem, Alan H. Diercks, Alissa C. Rothchild
This study shows alveolar macrophages have reduced LPS responses due to low TLR4/CD14 surface expression and lack IL-10 production, which is enhanced by type I IFN.
The Journal of Immunology · Mar 1, 2025Peer-reviewedImmunology