Alan H. Diercks

Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence

This study shows that ferroptosis, a form of cell death, is enhanced by a virulent Mtb strain, SA161, and inhibiting it reduces bacterial spread in mice.

Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis

This study uses single-cell RNA sequencing to identify immune dynamics distinguishing protection from susceptibility to tuberculosis in mice.

c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection

This study shows that c-Myc inhibition enhances macrophage antimycobacterial activity and reduces MTB persistence in both in vitro and in vivo models.

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

APOE Protects Against Severe Infection with Mycobacterium tuberculosis by Restraining Production of Neutrophil Extracellular Traps

This study shows that APOE protects against severe tuberculosis by limiting neutrophil extracellular trap formation, which exacerbates infection in Apoe-/- mice.

Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages

This study shows alveolar macrophages have reduced LPS responses due to low TLR4/CD14 surface expression and lack IL-10 production, which is enhanced by type I IFN.