Dat Mai

c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection

This study shows that c-Myc inhibition enhances macrophage antimycobacterial activity and reduces MTB persistence in both in vitro and in vivo models.

APOE Protects Against Severe Infection with Mycobacterium tuberculosis by Restraining Production of Neutrophil Extracellular Traps

This study shows that APOE protects against severe tuberculosis by limiting neutrophil extracellular trap formation, which exacerbates infection in Apoe-/- mice.

Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages

This study shows alveolar macrophages have reduced LPS responses due to low TLR4/CD14 surface expression and lack IL-10 production, which is enhanced by type I IFN.