NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection
Linh K. Pham, Maritza M. Cervantes, Pamelia N. Lim, Divya Dubey, Ankita Tufts, Tomoyo Shinkawa, Samuel M. Behar, Alissa C. Rothchild
This study shows NRF2 inhibits MHC II expression in alveolar macrophages during Mtb infection, impairing CD4+ T cell activation and host immunity.
bioRxiv · Aug 16, 2025 · PreprintImmunology