Author

Alan A. Aderem

Seattle Children's Research InstituteORCID 0000-0003-4031-5499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:scRNA-seq· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Alan H. DiercksiD· 3 shared Benjamin Henry GerniD· 2 shared Dat MaiiD· 2 shared John D. AitchisoniD· 2 shared Kevin B. UrdahliD· 2 shared Alissa C. RothchildiD· 1 shared Ana N. JahniD· 1 shared Andrew T. GustiniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

Alan H. DiercksORCID

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3 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedJun 28, 2025

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

Benjamin Henry Gern, Josepha M. Klas, Kimberly A. Foster…·Kevin B. Urdahl

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

45 citationstop 1%

mousescRNA-seq

𝕏 PostBluesky

ImmunologyPLoS PathogensPeer-reviewedJun 16, 2025

APOE Protects Against Severe Infection with Mycobacterium tuberculosis by Restraining Production of Neutrophil Extracellular Traps

Dong Liu, Dat Mai, Ana N. Jahn…·Elizabeth S. Gold

This study shows that APOE protects against severe tuberculosis by limiting neutrophil extracellular trap formation, which exacerbates infection in Apoe-/- mice.

15 citationstop 1%

mouseexperimental assay

𝕏 PostBluesky

ImmunologyThe Journal of ImmunologyPeer-reviewedMar 1, 2025

Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages

Pamelia N. Lim, Maritza M. Cervantes, Linh K. Pham…·Alissa C. Rothchild

This study shows alveolar macrophages have reduced LPS responses due to low TLR4/CD14 surface expression and lack IL-10 production, which is enhanced by type I IFN.

6 citations

mousebulk RNA-seq

𝕏 PostBluesky