Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells
Mirjam van Bentum, Bertram Klinger, Anja Sieber, Sheyda Naghiloo, Henrik Zauber, Nadine Lehmann, Mohamed Haji, Sylvia Niquet, Philipp Mertins, Nils Blüthgen, Matthias Selbach
The paper introduces SPIED-DIA, a phosphoproteomics method, to identify synergistic signaling responses in colon cancer cells to MEK inhibition and growth factor stimulation.
Nature Communications · May 26, 2025Peer-reviewedSystems Biology