Marcus Alexander Mall

Evolution of SARS-CoV-2 reshapes upper airway immunity in children

This study uses single-cell transcriptomics to show that SARS-CoV-2 variants reshape pediatric upper-airway immunity differently from adults.

A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

This paper develops a cell-permeable nanobody to restore function of the misfolded F508del-CFTR protein in CF bronchial epithelial cells.

Correcting mutant CFTR with a stabilizing nanobody reveals a novel active conformation of the channel

This study uses a nanobody to stabilize mutant CFTR, revealing a novel active conformation and improving its function in cystic fibrosis.

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

This study identifies age-related rewiring of type I IFN signaling in immune cells linked to increased inflammation and altered antibody responses in COVID-19.

Functional lung imaging identifies peripheral ventilation changes in mice with muco-obstructive lung disease

This study uses X-ray Velocimetry to identify peripheral ventilation changes in a mouse model of muco-obstructive lung disease.

Systemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the blood proteome

This study uses proteomics to compare the systemic effects of two CFTR modulator therapies in CF patients, finding that ELX/TEZ/IVA leads to proteome changes closer to healthy profiles.

ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.