Author

T. A. Fehniger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Gruszczynska· 1 shared A. Heard· 1 shared A. L. Dixon· 1 shared B. Johannesson· 1 shared D. Bhattacharya· 1 shared D. DeNardo· 1 shared E. H. Solloa· 1 shared E. Mace· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

A. Gruszczynska

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers

H. A. Pizzato, P. Alonso-Guallart, J. Woods, B. Johannesson, J. P. Connelly, T. A. Fehniger, J. Atkinson, S. M. Pruett-Miller, F. J. Monsma, D. Bhattacharya

This study genetically modifies human pluripotent stem cells to evade immune rejection in mice by knocking out HLA genes and adding inhibitory factors, leading to persistent teratomas in immunocompetent models.

bioRxiv · Jun 27, 2023Immunology

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

M. E. Selli, J. H. Landmann, M. Terekhova, J. Lattin, A. Heard, Y.-S. Hsu, T.-C. Chang, J. M. Warrington, H. Ha, N. Kingston, G. Hogg, M. Slade, M. M. Berrien-Elliot, M. Foster, S. Kersting-Schadek, , N. Singh

This study identifies that chronic activation of 41BB-based CARs leads to a novel T cell dysfunction state, distinct from exhaustion, which can be mitigated by disrupting FOXO3.

bioRxiv · Jan 26, 2023 · PreprintImmunology

CD56 regulates human NK cell cytotoxicity through Pyk2

J. Gunesch, A. L. Dixon, T. Ebrahim, M. Berrien-Elliott, S. Tatineni, T. Kumar, E. H. Solloa, T. A. Fehniger, E. Mace

This study shows CD56 enhances NK cell cytotoxicity by promoting exocytosis and signaling through Pyk2 phosphorylation.

bioRxiv · Mar 19, 2020Immunology