Author

I. D. Wolf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. J. Rubin· 5 shared C. Akusobi· 3 shared T. R. Ioerger· 3 shared B. S. Benghomari· 2 shared C. L. Dulberger· 2 shared J. Zhu· 2 shared S. Singhvi· 2 shared A. Muir· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersMicrobiology

E. J. Rubin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strains

C. Akusobi, S. Choudhery, B. S. Benghomari, I. D. Wolf, S. Singhvi, T. R. Ioerger, E. J. Rubin

This study uses transposon-sequencing to analyze functional genomic diversity across 21 Mycobacterium abscessus isolates, identifying essential and non-essential genes and previously uncharacterized genetic networks.

bioRxiv · Mar 29, 2023Microbiology

Chemically-induced targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

H. I. Won, J. Zhu, O. Kandror, T. Akopian, I. D. Wolf, M. C. Chao, M. Waldor, E. J. Rubin

This study uses a genetic system to screen essential proteins in Mycobacterium smegmatis, identifying labile targets for PROTACs and showing their potential to enhance antibiotic efficacy.

bioRxiv · Feb 14, 2023Microbiology

Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection

M. R. Sullivan, K. McGowen, Q. Liu, C. Akusobi, D. C. Young, J. A. Mayfield, S. Raman, I. D. Wolf, D. B. Moody, C. C. Aldrich, A. Muir, E. J. Rubin

This study identifies biotin-dependent fatty acid remodeling as essential for Mycobacterium abscessus survival in the lung, suggesting biotin synthesis and fatty acid metabolism as therapeutic targets.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

High-density transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivity

C. Akusobi, B. S. Benghomari, J. Zhu, I. D. Wolf, S. Singhvi, C. L. Dulberger, T. R. Ioerger, E. J. Rubin

bioRxiv · Jul 1, 2021Microbiology

A conserved translation factor is required for optimal synthesis of a membrane protein family in mycobacteria

S. Fishbein, I. D. Wolf, C. L. Dulberger, A. Wang, H. Keshishian, L. Wallace, S. A. Carr, T. R. Ioerger, E. J. Rubin, E. H. Rego

This study identifies LepA as a conserved GTPase that enhances the synthesis of mycobacterial porins, affecting drug tolerance and membrane permeability.

bioRxiv · Dec 11, 2019 · PreprintMicrobiology