Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation
K. Nagata, D. Ando, T. Ashikari, K. Ito, R. Miura, I. Fujigaki, M. Ando, N. Ito, H. Kawazoe, Y. Iizuka, M. Inoue, T. Yashiro, M. Hachisu, K. Kasakura, C. Nishiyama
This study shows that butyrate and valerate reduce IgE-mediated mast cell activation by enhancing PGE2 release and GPR109A signaling, while niacin also alleviates anaphylaxis through similar mechanisms.
bioRxiv · Feb 19, 2023Immunology