The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis
K. Moriwaki, C. Park, K. Koyama, S. Balaji, K. Kita, R. Yagi, S. Komazawa-Sakon, T. Asuka, H. Nakano, Y. Kamada, E. Miyoshi, F. Chan
This study shows that RIPK1's scaffold function in dendritic cells prevents colonic inflammation and maintains immune homeostasis by inhibiting apoptosis and necroptosis.
bioRxiv · Feb 27, 2021Immunology