Author

T. C. Fitch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Organism:human· 1

Frequent Co-Authors

C. M. Donnelly· 2 shared J. A. Joseph· 2 shared J. Ahmed· 2 shared S. Kumar· 2 shared A. G. Thomas· 1 shared A. Ledreux· 1 shared A. Son· 1 shared C. Zhang· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

C. M. Donnelly

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2 papers

Recent·Most cited

A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinsons Phenotypes

S. Kumar, N. H. Stillman, J. A. Joseph, J. Ahmed, R. A. Dohoney, T. D. Ball, A. G. Thomas, T. C. Fitch, C. M. Donnelly

This paper develops a 2D-FAST method to identify antagonists of α-synuclein aggregation, showing efficacy in C. elegans models of Parkinson's disease.

bioRxiv · Jul 11, 2022 · PreprintBiochemistry

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

J. Ahmed, T. C. Fitch, C. M. Donnelly, J. A. Joseph, M. M. Bassil, A. Son, C. Zhang, A. Ledreux, S. Horowitz, Y. Qin, D. Paredes, S. Kumar

This study identifies and validates novel therapeutic targets for Parkinson's disease by analyzing α-Synuclein self-assembly using foldamers and multiple assays.

bioRxiv · May 8, 2021Biochemistry