Author

T. C. McLean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:structural biology· 1

Frequent Co-Authors

C. M. Thomas· 2 shared B. T. Chait· 1 shared C. A. Elg· 1 shared C. Aicart-Ramos· 1 shared D. M. Lawson· 1 shared E. A. Campbell· 1 shared E. M. Top· 1 shared E. Mack· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

C. M. Thomas

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Author profile →

2 papers

Recent·Most cited

Molecular switching of a DNA-sliding clamp to a repressor mediates long-range gene silencing

T. C. McLean, F. Balaguer-Perez, J. Chandanani, C. M. Thomas, C. Aicart-Ramos, S. Burick, P. D. B. Olinares, G. Gobbato, J. E. A. Mundy, B. T. Chait, D. M. Lawson, S. A. Darst, E. A. Campbell, F. Moreno-Herrero, T. B. K. Le

The paper shows that KorB, a DNA-sliding clamp, switches to a repressor role with KorA to mediate long-range gene silencing on plasmid RK2.

bioRxiv · Feb 16, 2024 · PreprintMicrobiology

Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost

C. A. Elg, E. Mack, M. Rolfsmeier, T. C. McLean, O. Kosterlitz, E. Soderling, S. Narum, P. A. Rowley, C. M. Thomas, E. M. Top

This study shows that inactivating the upf31 gene in a plasmid improves its maintenance in E. coli by altering gene regulation, demonstrating how plasmid evolution can affect host range.

bioRxiv · Feb 5, 2024Microbiology