E. M. Top

Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost

This study shows that inactivating the upf31 gene in a plasmid improves its maintenance in E. coli by altering gene regulation, demonstrating how plasmid evolution can affect host range.

Evolutionary crowdsourcing: alignment of fitness landscapes allows cross-species adaptation of a horizontally transferred gene

The paper examines how horizontal gene transfer affects gene evolution across species by aligning fitness landscapes and shows that adaptive evolution in one species can translate to another.

Antimicrobial resistance genes predict plasmid generalism and network structure in wastewater

The paper uses Hi-C data to show AMR-carrying plasmids form more connected networks than non-AMR plasmids, enhancing AMR gene spread.

Biofilms preserve transmissibility of a multi-drug resistance plasmid

This study shows biofilms help MDR plasmids persist longer without antibiotics compared to planktonic populations, and favor horizontal transfer.

A Broadly Conserved Deoxycytidine Deaminase Protects Bacteria from Phage Infection

The study identifies DcdV, a deoxycytidine deaminase in V. cholerae, as a novel phage defense mechanism conserved across bacteria and eukaryotes.

Estimating the rate of plasmid transfer with an adapted Luria-Delbrück fluctuation analysis

This paper introduces a new method to estimate plasmid transfer rates between bacterial cells, showing it is more accurate than existing methods.

Contagious Antibiotic Resistance: Plasmid Transfer Among Bacterial Residents of the Zebrafish Gut

This paper investigates plasmid transfer among zebrafish gut bacteria, showing that resistance spread depends on donor-recipient species combinations and highlights rare members as potential plasmid reservoirs.

Linking the Resistome and Plasmidome to the Microbiome

This study uses Hi-C to identify the in situ host range of antibiotic resistance genes, plasmids, and integrons in wastewater, revealing their associations with host genomes.

The transferable resistome of produce

This study identifies diverse transferable antibiotic resistance plasmids in produce-associated bacteria using cultivation and DNA-based methods, showing that enrichment improves detection of these plasmids.

Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance

This study identifies common evolutionary mechanisms that stabilize antibiotic resistance plasmids across different host-plasmid pairs.