Author

T. C. Sudhof

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:synaptic & neural circuits· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. R. Dunn· 1 shared A. Sebin· 1 shared B. Cui· 1 shared B. Haddad Derafshi· 1 shared B. L. Zhong· 1 shared C. E. Lee· 1 shared C. S. Peng· 1 shared D. Arac· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperBiophysics

A. R. Dunn

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4 papers

Recent·Most cited

Piconewton forces mediate GAIN domain dissociation of the latrophilin-3 adhesion GPCR

B. L. Zhong, C. E. Lee, V. T. Vachharajani, T. C. Sudhof, A. R. Dunn

This study shows that physiological forces accelerate GAIN domain dissociation of latrophilin-3, suggesting mechanical force drives aGPCR signaling during synapse formation.

bioRxiv · Jan 12, 2023Biophysics

Nanometer-Resolution Long-term Tracking of Single Cargos Reveals Dynein Motor Mechanisms

C. S. Peng, Y. Zhang, Q. Liu, G. E. Marti, Y.-W. A. Huang, T. C. Sudhof, B. Cui, S. Chu

This study uses single-particle tracking to analyze dynein motor behavior in live neurons, revealing that dynein switches between 1-5 motors and requires 2 ATP hydrolysis per step.

bioRxiv · Jan 5, 2022 · PreprintBiophysics

The Autism Risk Factor CHD8 Is a Chromatin Activator and Functionally Dependent on the ERK-MAPK Pathway Effector ELK1

B. Haddad Derafshi, T. Danko, S. Chanda, P. Batista, U. Litzenburger, Q. Y. Lee, Y. H. Ng, A. Sebin, H. Y. Chang, T. C. Sudhof, M. Wernig

This study identifies CHD8 as a chromatin activator in human neurons that depends on the ERK-MAPK pathway effector ELK1 for its function.

bioRxiv · Nov 10, 2020Cell Biology

Structure of the teneurin-latrophilin complex: Alternative splicing controls synapse specificity by a novel mechanism

J. Li, Y. Xie, S. Cornelius, X. Jiang, S. P. Kordon, R. Sando, M. Pan, K. Leon, T. C. Sudhof, M. Zhao, D. Arac

The paper reports the cryo-EM structure of the Tenm2-Lphn3 complex and shows how alternative splicing regulates synapse specificity by affecting access to the Lphn-binding site.

bioRxiv · Jan 13, 2020Biochemistry