Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
G. Shi, A. I. Chiramel, K. K. Lai, A. Kenney, T. Li, T. Dempsey, A. Zani, L. Zhang, S. Majdoul, S. Das, P. A. Beare, S. Kar, T. Andresson, S. M. Best, J. S. Yount, A. A. Compton
This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.
bioRxiv · Apr 15, 2021Microbiology