Author

K. K. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. Shi· 2 shared T. Li· 2 shared A. A. Compton· 1 shared A. A. Kossiakoff· 1 shared A. Compton· 1 shared A. D. Finzi· 1 shared A. I. Chiramel· 1 shared A. Kenney· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

G. Shi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

G. Shi, T. Li, K. K. Lai, R. F. Johnson, J. Yewdell, A. Compton

This study shows Omicron SARS-CoV-2 has higher infectivity and interferon resistance in human nasal tissue compared to Delta, due to changes in Spike protein entry mechanisms.

bioRxiv · May 6, 2023Microbiology

CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter

S. A. Leonhardt, M. D. Purdy, J. R. Grover, Z. Yang, S. Poulos, W. E. McIntire, E. A. Tatham, S. Erramilli, K. Nosol, K. K. Lai, S. Ding, M. Lu, P. D. Uchil, A. D. Finzi, A. Rein, , M. Yeager

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

bioRxiv · Jul 6, 2022 · PreprintBiophysics

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

G. Shi, A. I. Chiramel, K. K. Lai, A. Kenney, T. Li, T. Dempsey, A. Zani, L. Zhang, S. Majdoul, S. Das, P. A. Beare, S. Kar, T. Andresson, S. M. Best, J. S. Yount, A. A. Compton

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

bioRxiv · Apr 15, 2021Microbiology