T. Andresson

Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid Assembly

This paper develops a 3D self-assembly system to engineer tumor stroma-like structures using decellularized ECM and cancer cells, showing effects on malignancy and metabolism.

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Metabolism-focused CRISPR screen unveils Mitochondrial Pyruvate Carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer

The paper identifies MPC1 as a key driver of PARP inhibitor resistance in NSCLC lung cancer through a metabolism-focused CRISPR screen.

A virus-induced circular RNA maintains latent infection of Kaposi sarcoma herpesvirus

This study identifies a virus-induced circular RNA, hsa_circ_0001400, that promotes KSHV latency by inhibiting lytic replication and enhancing cell survival.

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers

This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.

3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

This study identifies a mechanism where 3'UTR-directed mRNA decay inhibits C/EBPβ activation, suppressing senescence in tumor cells and promoting tumor progression.

Protonation-Dependent Sequencing of 5-Formylcytidine in RNA

This paper develops a protonation-dependent sequencing method to detect 5-formylcytidine and 5-carboxycytidine in RNA, demonstrating its application in human tRNA and a 5fC-deficiency model.

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.

A systems chemoproteomic analysis of acyl-CoA/protein interactions

The paper develops a chemoproteomic platform to analyze acyl-CoA/protein interactions and identifies biological processes affected by acetyl-CoA levels.