Author

T. Dendooven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Organism:bacteria (other)· 2 Research Focus:benchmarking· 2 Approach:deep learning· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

A. Burt· 2 shared D. Barford· 2 shared J. Schwab· 2 shared J. Yang· 2 shared S. H. McLaughlin· 2 shared S. Yatskevich· 2 shared Z. Zhang· 2 shared B. F. Luisi· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

A. Burt

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Author profile →

5 papers

Recent·Most cited

DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images

J. Schwab, D. Kimanius, A. Burt, T. Dendooven, S. Scheres

DynaMight improves cryo-EM reconstruction by estimating molecular motions through 3D deformation learning and error estimation using VAEs.

bioRxiv · Oct 18, 2023Biophysics

Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere

T. Dendooven, Z. Zhang, J. Yang, S. H. McLaughlin, J. Schwab, S. H. W. Scheres, S. Yatskevich, D. Barford

The paper determines the cryo-EM structure of the complete inner kinetochore of budding yeast, revealing its architecture and DNA interactions.

bioRxiv · Dec 12, 2022Biochemistry

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

S. Yatskevich, K. W. Muir, D. Bellini, Z. Zhang, J. Yang, T. Tischer, M. Predin, T. Dendooven, S. H. McLaughlin, D. Barford

The paper describes the cryo-EM structure of the human inner kinetochore CCAN complex bound to a CENP-A nucleosome, revealing how it grips linker DNA for chromosome segregation.

bioRxiv · Jan 7, 2022Biochemistry

Tools enabling flexible approaches to high-resolution subtomogram averaging

A. Burt, L. Gaifas, T. Dendooven, I. Gutsche

The paper introduces computational tools for subtomogram averaging in cryo-electron tomography, demonstrating their application to HIV-1 and bacterial datasets.

bioRxiv · Jan 31, 2021 · PreprintBiophysics

Architectural principles for Hfq/Crc-mediated regulation of gene expression

B. F. Luisi, X. Y. Pei, T. Dendooven, E. Sonnleitner, S. Chen, U. Blasi

This study presents high-resolution cryo-EM structures of Hfq and Crc bound to an RNA, revealing their cooperative assembly and mechanism of gene regulation in Pseudomonas aeruginosa.

bioRxiv · Nov 6, 2018Biophysics