D. Bellini

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

Structure of the human outer kinetochore KMN network complex

The paper determines the high-resolution cryo-EM structure of the human KMN network, revealing its subunit organization and phosphorylation-dependent regulation.

PRC domain-containing proteins modulate FtsZ-based archaeal cell division

This study identifies PRC domain proteins as essential components of the FtsZ-based cell division machinery in archaea, showing they form complexes with SepF and FtsZ and are required for proper cell division.

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

The paper describes the cryo-EM structure of the human inner kinetochore CCAN complex bound to a CENP-A nucleosome, revealing how it grips linker DNA for chromosome segregation.

A drug discovery-oriented non-invasive protocol for protein crystal cryoprotection by dehydration, with application for crystallization screening.

This paper introduces a non-invasive cryoprotection protocol using KF13 to improve drug discovery by enhancing diffraction resolution and ligand binding in protein crystal screening.

Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes

This study characterizes the ubiquitin-ESCRT pathway in Asgard archaea, showing its pre-eukaryotic origin and evolutionary path through gene duplication.

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.