Author

T. Tischer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

D. Barford· 3 shared J. Yang· 2 shared C. Lindon· 1 shared C. Okoye· 1 shared C. Phillips· 1 shared C. Stubbs· 1 shared D. Bellini· 1 shared D. Spring· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

D. Barford

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Author profile →

3 papers

Recent·Most cited

Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

R. Eapen, C. Okoye, C. Stubbs, M. Schimpl, T. Tischer, E. J. Fisher, M. Zacharopoulou, F. Ferrer, D. Barford, D. Spring, C. Lindon, C. Phillips, L. S. Itzhaki

This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.

bioRxiv · Apr 30, 2024Biochemistry

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

S. Yatskevich, K. W. Muir, D. Bellini, Z. Zhang, J. Yang, T. Tischer, M. Predin, T. Dendooven, S. H. McLaughlin, D. Barford

The paper describes the cryo-EM structure of the human inner kinetochore CCAN complex bound to a CENP-A nucleosome, revealing how it grips linker DNA for chromosome segregation.

bioRxiv · Jan 7, 2022Biochemistry

Negative feedback between the APC/C and Cep152 at the centrosome regulates mitotic spindle assembly

T. Tischer, J. Yang, D. Barford

The paper shows that APC/C and Cep152 interact at centrosomes during mitosis, with APC/C regulating Cep152 levels to control spindle assembly and chromosome segregation.

bioRxiv · Mar 23, 2020Cell Biology