Potent programmable antiviral against dengue virus in primary human cells by Cas13b RNP with short spacer and delivery by virus-like particle
E. Singsuksawat, S. Onnome, P. Posiri, A. Suphatrakul, N. Srisuk, R. Nantachokchawapan, H. Praneechit, C. Sae-kow, P. Chidpratum, S. Hongeng, P. Avirutnan, T. Duangjinda, B. Siridechadilok
This study demonstrates that PspCas13b RNP delivered by virus-like particles can efficiently suppress dengue virus infection in primary human cells using short spacers.
bioRxiv · May 17, 2020Microbiology