Author

T. Yuwen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Hessel· 1 shared A. Shilova· 1 shared C. R. Knoverek· 1 shared E. Rennella· 1 shared G. R. Bowman· 1 shared I. Ayala· 1 shared J. Woodhouse· 1 shared J.-P. Colletier· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Hessel

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2 papers

Recent·Most cited

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

C. R. Knoverek, U. L. Mallimadugula, S. Singh, E. Rennella, T. E. Frederick, T. Yuwen, S. Raavicharla, L. E. Kay, G. R. Bowman

The paper investigates how a cryptic pocket in β-lactamase, formed under the Ω-loop, enhances enzyme activity against penicillin, suggesting excited states can improve function.

bioRxiv · Apr 14, 2021Biophysics

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

V. Kurauskas, S. A. Izmailov, O. N. Rogacheva, A. Hessel, I. Ayala, J. Woodhouse, A. Shilova, Y. Xue, T. Yuwen, N. Coquelle, J.-P. Colletier, N. R. Skrynnikov, P. Schanda

This study investigates how crystal packing affects microsecond dynamics of ubiquitin using solid-state NMR and MD simulations, revealing altered thermodynamics and kinetics of conformational exchange.

bioRxiv · Jun 2, 2017Biophysics