T. Flatt

An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation

This study investigates the population genomics of an inversion polymorphism in Drosophila melanogaster across four continents, finding evidence of balancing selection and climate-driven distribution patterns.

Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity

The paper validates the role of Doa alleles in Drosophila lifespan and fecundity using transgenic RNAi and genetic association approaches.

Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans

This study investigates how host-microbe interactions influence life history and aging in C. elegans, showing genotype-dependent effects on reproductive aging and survival.

A single nucleotide variant in the PPARgamma-homolog Eip75B affects fecundity in Drosophila

The paper identifies a SNP in Eip75B affecting fecundity and egg-to-adult viability in Drosophila, but not longevity.

Supergene degeneration opposes polymorphism: The curious case of balanced lethals

This study uses simulations to explore how mutation accumulation and asymmetric degradation affect the stability of supergene polymorphisms and the emergence of balanced lethal systems.

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

Gene co-expression network reveals highly conserved, well-regulated anti-ageing mechanisms in old ant queens.

The paper analyzes gene co-expression networks in old ant queens to identify anti-ageing mechanisms and finds increased transcriptional regulation and strong purifying selection on key genes.

The discovery, distribution and diversity of DNA viruses associated with Drosophila melanogaster in Europe

The paper identifies and characterizes DNA viruses in Drosophila melanogaster across Europe, revealing new viral lineages and prevalence patterns.

A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila

This study examines how natural variants in the foxo gene, part of the insulin signaling pathway, affect life-history traits in Drosophila across different environmental conditions.

Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly

The paper shows that adaptation to different developmental diets affects the response to selection on age at reproduction in fruit flies, with interactions between selection regimes across life stages.

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster

This study shows that allelic variation at foxo affects body size and starvation tolerance in Drosophila melanogaster, mirroring latitudinal patterns in natural populations.